THE EFFECTIVENESS OF FLUID RINGER ACETATE MALAT COMPARED WITH RINGER LACTATE FLUID IN ACCELERATING TIME INCREASE IN BLOOD PRESSURE IN RATS (RATTUS NORVEGICUS)

Abstract

Dehydration is described as a state of disturbed fluid balance that can be caused by various types of disease. One of the signs and symptoms of dehydration is a decrease in blood pressure. Dehydration occurs due to loss of water more than on the water inlet. Fluid administration is one of the measures taken to overcome the problem of dehydration. Ringer Acetate Malate fluids containing electrolytes are balanced with concentrations similar to those found in human plasma. Ringer Lactate fluid is a crystalloid liquid that is widely used in fluid therapy. The levels of sodium in the crystalloid solution called Ringer Acetate Malate is more similar with the plasma of the human body than Ringer lactate therefore Ringer Acetate Malate more isotonic than Ringer Lactate. Acetate metabolism also obtained 3-4 times faster than Lactate. Experimental animals used in this study were white rats (rattus norvegicus) totaling 14 samples. This study aims to determine the effectiveness between the administration of Ringer Acetate Malate fluid compared with Ringer Lactate fluid in accelerating time increase in blood pressure in rats. Type of research is quantitative research, design true eksperimental approach pra test- post test group design. Data collection using observation. Data were analyzed by Independent T Test statistical test to determine differences in Ringer Acetate Malate fluid and Ringer Lactate fluid in rats. Based on the survey results revealed that the increase in blood pressure in rats by administration of Ringer Acetate Malate fluid there is an increased and accelerated the volume of urine produced by the average amount of 0.3625 cc in less than 2 hours. While Ringer Lactate for fluid administration in increasing blood pressure and accelerate time amount of urine produced volume is 0.275 cc within 2 hours or more. The results of statistical tests using Independent T Test found the difference between giving Ringer Acetate Malate fluids with Ringer's Lactate with values obtained α = 0.017. Conclusions from this study that there is a difference between giving fluids Ringer Acetate Malate with Ringer Lactate fluid in accelerating time increase in blood pressure in rats. Increased blood pressure more quickly by providing fluid Ringer Acetate Malat than using fluid Ringer Lactate.